NanoBiology is the intersection between nanotechnology and biology. Traditionally, the cell is the domain of biologists and medical researchers. However, physical processes are at work on the cellular level. Knowledge of physics (on the nano-scale) is essential for a good understanding of these processes, knowledge that biologists and medical researchers typically do not possess. At the same time, physicists are not acquainted with the behavior of cells and as a result are not able to interpret physical processes in the cell. To be able to understand the basis of health and disease, knowledge of both physics and molecular biology is essential. NanoBiology is the discipline where biology, specifically the basic biology of human health and disease, and nanophysics meet.

Applied Nanobiology is what we do best at Artoss. The inventor of NanoBone, Dr. rer. nat. Thomas Gerber has spent a career studying nanotechnology as it relates to biology - the embodiment of Nanobiology. To this day, Professor Gerber is the chair of Nanostructured Materials at the University of Rostock Physics Institute.

HARNESSING THE POWER OF NANOBIOLOGY

NanoBone consists of nanocrystals of hydroxyapatite (HA) dispersed in an amorphous silica gel matrix (ASG). The HA nanocrystals have similar size, chemistry, and morphology to the HA in human bone. These nanocrystals are not bound to one another and autologous proteins adsorb rapidly to the surface.

The ASG that holds the HA nanocrystals in place is highly nanoporous with an extremely large internal surface area that attracts autologous proteins that are critical for new bone formation. ASG is also very hydrophilic and releases silicon dioxide, which triggers angiogenesis and new bone formation.

HA Nano Crystals
SIO2
NanoBone diagram

Following implantation, the amorphous silica gel is rapidly replaced by an autologous organic matrix. Once the organic matrix is in place, the process of cell-mediated bone formation and resorption proceeds.

The very large internal surface area of NanoBone strongly attracts and binds autologous osteopontin, osteocalcin, and BMP-2 molecules that are critical for new bone formation. The internal surface area also determines the resorption rate of bone grafts. In clinical cases, NanoBone is completely converted to autologous bone in as little as 12-14 months.

NanoBone Diagram